Endocrine Abstracts

Pituitary apoplexy is a rare condition and gestational pituitary apoplexy (GPA) is even more exceptional. Clinical presentation of GPA is often non-specific overlapping with other conditions, making its diagnosis challenging. Additionally, therapeutic management is often limited since it depends on both the mother’s and the fetus’s prognosis. Herein we report of a woman who was diagnosed with GPA and we discuss the management of her case. A 34-year-old woman with no ...

Introduction: Turner syndrome (TS) is a feminine chromosomic disease, defined as the partial or total loss of the X chromosome. Classic phenotype includes growth and pubertal retardation as well as a characteristic dysmorphic syndrome. Other accompanying comorbidities are frequently associated with TS such as metabolic diseases: overweight, diabetes, hypertension (HTA) and dyslipidemia. Through this report we aim to determine the frequency of metabolic diseases associated with...

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy affecting women of reproductive age. PCOS has two phenotypes, obese and lean, the latter being a much less common presentation of the syndrome.Aim: Compare PCOS outcomes in patients with obese PCOS and patients with lean PCOS.Methods: A retrospective, single-center, descriptive and comparative study including patients with PCOS followed at the endocrinology d...

Introduction: Polycystic ovary syndrome (PCOS) is occurring in approximately one in seven women. Infertility is a major issue in PCOS. Recognizing patients with higher risk of infertility is still a matter of debate.Aim: Study the predictive factors of female infertility in patients with PCOSMethods: A retrospective, single-center, comparative and analytical study including patients with PCOS followed at the endocrinology departmen...

Introduction: Turner syndrome (TS) is a genetic disease, attributable to the total or partial loss of an X chromosome. The classic phenotype encompasses short stature, hypergonadotropic hypogonadism and dysmorphic features. It’s also associated with other conditions such as autoimmune (AI) diseases. Aim: Herein we aim to determine the frequency of AI diseases in TS and to identify the genetic variants of TS mostly associated with this latter conditi...

Introduction: Hyperprolactinemia is a relatively frequent finding. A wide range of conditions can be responsible of this biochemical abnormality. Herein we report a rather rare etiology of hyperprolactinemia which is Turner syndrome (TS).Methods: Aiming to determine the frequency of hyperprolactinemia in patients with TS, we enrolled a retrospective descriptive study in the department of Endocrinology at the Hedi Chaker Hospital. We included patients who...

Introduction: Addison disease (AD) is associated with high risk of decreased bone mineral density (BMD) and osteoporosis. Causes are complex, including lifelong glucocorticoid replacement therapy. Several studies have pointed a significant relationship between glucocorticoid dose and low BMD in patients with AD. The aim of our study is to assess the impact of glucocorticoid replacement dose on BMD among Tunisian patients with AD.Patients and Methods: We ...

Introduction: Inappropriate glucocorticoid replacement therapy results in higher mortality rates in patients with Addison disease (AD), predominantly due to higher prevalence of cardiovascular diseases, disturbed glycometabolic state and altered anthropometric parameters. The aim of this study was to assess the impact of life-long corticosteroid exposure on anthropometric parameters in patients with AD.Patients and Methods: This Tunisian cross-sectional ...

Introduction: Glucocorticoid replacement therapy may result in long-term morbidities, including cardiovascular diseases which can increase cardiovascular risk. The study was aimed to assess the impact of life-long glucocorticoid replacement therapy on cardiovascular parameters in patients with Addison disease (AD).Patients and Methods: This cross-sectional study was conducted assess cardiovascular events in patients followed for AD for at least 5 years, ...

Objective: To assess the prevalence of obesity and metabolic disorders in patients with non-functional pituitary adenomas (NFPA)Patients and methods: A retrospective descriptive study of 35 patients followed for NFPA between 2000 and 2022. Metabolic syndrome was established according to the National Cholesterol Education Program Adult Treatment Panel III criteria.Results: The mean age was 52.1±11.4 years, with a male predomina...